Cohort #3: “high dose” hGRP transplantation with FK-506/Rapamycin did not protect respiratory function or cervical motor neurons.

<p>Greater cell survival was found with the “high dose” transplants compared to “low dose” transplants, with a greater proportion of cells localizing to gray matter than white matter (<b>A</b>). Transplant-derived cells migrated from injection sites up to distances of 6 mm (<b>B</b>). All SOD1^G93A animals had significantly reduced phrenic CMAP amplitudes at 130 days of age, however, there was no significant difference between hGRP and hF groups (<b>C</b>). There was no difference in cervical motor neuron survival between mice receiving hGRP and hF transplants at disease endstage (<b>D</b>).